ASCOTA changes its name to the Association of Student Delegates (ASD). Occupational therapy is recognized as a core discipline for working with persons with genetic conditions on the basis of NIH funding.

AOTA adopts the Occupational Therapy Practice Framework: Domain and Process to replace Uniform Terminology. The Association pilots a 10-state Listserv, the Evolution of Communication, to keep members up-to-date on issues important to the profession. AOTA Press becomes the Association’s publishing brand. The Fund to Promote Awareness of Occupational Therapy is established.

The Consolidated Appropriations Act of 2004 (P.L. 108-199) allocates a small amount for training in research-based interventions for patients and caregivers dealing with Alzheimer's disease, including occupational therapy. The Individuals with Disabilities Education Improvement Act (P.L. 108-446) continues support for occupational therapy provided by qualified practitioners.

AOTA and ACOTE sign a memorandum of understanding, giving ACOTE “unfettered autonomy for establishing standards for educational programs.”

AOTA adopts the Centennial Vision, which states that “We envision that occupational therapy is a powerful, widely recognized, science-driven, and evidence-based profession with a globally connected and diverse workforce meeting society’s occupational needs.”

The revised ACOTE standards include criteria for entry-level doctoral-degree programs and entry-level master’s degree programs for OTs. AOTA adopts the Occupational Therapy Practice Framework, 2nd Edition.